NLK

Across TCGA patient cohorts, NLK mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLK-associated genes across cancer lineages are p38-MAPK_pT180_Y182, PCNA, and TIGAR. Each is linked with NLK in more than 1 cancer types. Because this analysis shows association rather than direction, both NLK-to-partner and partner-to-NLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by NLK-low versus NLK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLK→partner) and Y-score (partner→NLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.498	-1.664	.003	.023	3	2
UCEC	PCNA →	+0.307	+2.087	<.001	.005	3	2
UCEC	TIGAR →	+0.169	+2.114	.003	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.610	+1.720	.007	.025	3	2
UCEC	14-3-3_beta →	-0.090	-2.295	.020	.033	3	1
UCEC	eEF2 →	+0.374	+1.874	.006	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

p38-MAPK_pT180_Y182 by NLK expression — UCEC

Explore this box plot interactively →