NLK

Across TCGA cell cohorts, NLK mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLK-associated genes across cancer lineages are SIRPD, TNP1, and H2BW1. Each is linked with NLK in more than 1 cancer types. Because this analysis shows association rather than direction, both NLK-to-partner and partner-to-NLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIRPD grouped by NLK-low versus NLK-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLK→partner) and Y-score (partner→NLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SIRPD →	+0.058	+5.029	<.001	.006	3	1
SOFT_TISSUE	TNP1 →	+1.481	+5.369	<.001	.004	3	1
SOFT_TISSUE	H2BW1 →	+0.030	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR1M1 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	1
BLOOD_Lymphoma	OR14A16 →	+0.016	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SIRPD by NLK expression — LUNG_SCLC

Explore this box plot interactively →