NLGN4Y

Across TCGA patient cohorts, NLGN4Y mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. COAD shows the largest number of these associations.

The most reproducible NLGN4Y-associated genes across cancer lineages are MIG-6, ASNS, and 14-3-3_epsilon. Each is linked with NLGN4Y in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN4Y-to-partner and partner-to-NLGN4Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by NLGN4Y-low versus NLGN4Y-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN4Y→partner) and Y-score (partner→NLGN4Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.101	+3.381	.030	.004	3	2
COAD	ASNS →	+0.395	+2.178	.034	.035	3	2
COAD	14-3-3_epsilon →	+0.144	+3.364	.017	.005	3	1
COAD	PREX1 →	+0.207	+2.195	.034	.034	3	1
COAD	Tuberin →	-0.336	-3.000	.026	.035	3	1
COAD	Bad_pS112 →	-0.225	-2.974	.014	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MIG-6 by NLGN4Y expression — COAD

Explore this box plot interactively →