Across TCGA pan-cancer cohorts, NLGN4Y-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NLGN4Y-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NLGN4Y-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NLGN4Y-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, CHOL, and LUAD are the cancer types where NLGN4Y-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLGN4Y-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	IV	−0.449	.002	8	view →
CHOL	All	II,III,IV	+0.625	<.001	4	view →
LUAD	Male	II,III,IV	+0.329	.020	2	view →
THCA	Male	IV	−0.446	.023	1	view →
STAD	Male	IV	−0.180	.003	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: NLGN4Y-AS1 RNA expression & survival · all NLGN4Y-AS1 data types