NLGN4X

Across TCGA pan-cancer cohorts, NLGN4X Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated NLGN4X data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NLGN4X Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NLGN4X expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, BLCA, and KICH are the cancer types where NLGN4X Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.957	0.614	.001	34	view →
BLCA	OS	Median	All	0.247	0.610	.029	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
SKCM	DFS	Median	IV	1.000	0.227	.011	10	view →
ACC	OS	Median	All	0.188	0.820	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	.001	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
STAD	OS	Median	II,III,IV	0.863	0.660	.031	3	view →
KIRP	OS	Median	All	0.192	0.704	.040	2	view →
CESC	DFS	Median	II,III,IV	0.481	0.791	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NLGN4X–UCEC (DFS)

Open the UCEC breakdown →