Across TCGA patient cohorts, NLGN3 mutation is significantly associated with the RNA expression of many other genes, with 4,507 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN3-associated genes across cancer lineages are BUB3, SKA1, and DTYMK. Each is linked with NLGN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLGN3-to-partner and partner-to-NLGN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN3→partner) and Y-score (partner→NLGN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	BUB3 →	+0.370	+3.635	<.001	.001	3	4
UCEC	SKA1 →	+0.517	+2.021	<.001	<.001	3	4
UCEC	DTYMK →	+0.386	+1.353	<.001	<.001	3	4
UCEC	TMEM9B →	+0.339	+1.404	<.001	<.001	3	4
UCEC	TMEM11 →	+0.230	+1.321	.001	<.001	3	4
COAD	TMEM107 →	+0.485	+3.605	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,507 associations by consensus.

Exploration

NLGN3 survival (RNA) · tumor vs normal (RNA) · all NLGN3 data types