Across TCGA patient cohorts, NLGN3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN3-associated genes across cancer lineages are ASNS, eIF4E, and GAPDH. Each is linked with NLGN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLGN3-to-partner and partner-to-NLGN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN3→partner) and Y-score (partner→NLGN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.316	+2.070	<.001	.001	3	4
UCEC	eIF4E →	+0.157	+1.402	.003	<.001	3	3
UCEC	GAPDH →	+0.354	+1.662	.009	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.526	+1.353	<.001	.011	3	3
COAD	14-3-3_beta →	-0.226	-3.153	.014	.018	3	2
COAD	FASN →	+0.414	+2.330	.018	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Exploration

NLGN3 survival (RNA) · tumor vs normal (RNA) · all NLGN3 data types