Across TCGA cell cohorts, NLGN3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NLGN3-associated genes across cancer lineages are RESP18, OR4C12, and OTC. Each is linked with NLGN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN3-to-partner and partner-to-NLGN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN3→partner) and Y-score (partner→NLGN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RESP18 →	+0.033	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OTC →	+0.024	+4.371	<.001	.005	3	1
BLOOD_Leukemia	TCF23 →	+0.794	+3.855	.001	.007	3	1
BLOOD_Leukemia	RPL10L →	+0.028	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CYP7A1 →	+0.019	+4.285	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

NLGN3 survival (RNA) · tumor vs normal (RNA) · all NLGN3 data types