NLGN2

Across TCGA patient cohorts, NLGN2 protein abundance is significantly associated with the RNA expression of many other genes, with 5,663 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NLGN2-associated genes across cancer lineages are ADGRE5, ITGB2, and MARCO. Each is linked with NLGN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN2-to-partner and partner-to-NLGN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLGN2 versus ADGRE5 in LSCC, with a Pearson correlation of -0.87.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN2→partner) and Y-score (partner→NLGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRE5 →	-1.543	-1.206	.005	.003	2	2
LSCC	ITGB2 →	-2.354	-1.206	.006	.003	2	2
LSCC	MARCO →	-3.964	-1.206	<.001	.003	2	2
LSCC	TRGV5 →	-1.286	-1.206	.007	.003	2	2
LSCC	CCDC200 →	-0.783	-1.206	.006	.003	2	2
LSCC	NAIP →	-1.104	-1.206	.009	.003	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

NLGN2 vs ADGRE5 — LSCC

Explore this scatter interactively →