NLGN2

Across TCGA patient cohorts, NLGN2 mutation is significantly associated with the RNA expression of many other genes, with 3,600 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN2-associated genes across cancer lineages are SS18L2P1, MIR8053, and RN7SL690P. Each is linked with NLGN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLGN2-to-partner and partner-to-NLGN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SS18L2P1 grouped by NLGN2-low versus NLGN2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN2→partner) and Y-score (partner→NLGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SS18L2P1 →	+0.292	+5.306	<.001	.006	3	3
UCEC	MIR8053 →	+0.120	+2.675	.006	.003	3	3
BLCA	RN7SL690P →	+0.238	+5.788	<.001	.003	3	2
CESC	MIR1278 →	+0.592	+5.418	<.001	.005	3	2
LIHC	POTEF-AS1 →	+0.194	+6.676	<.001	<.001	3	2
LGG	MTND6P1 →	+0.074	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,600 associations by consensus.

SS18L2P1 by NLGN2 expression — CESC

Explore this box plot interactively →