NLGN2

Across TCGA patient cohorts, NLGN2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN2-associated genes across cancer lineages are ATM, MSH6, and Notch1. Each is linked with NLGN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLGN2-to-partner and partner-to-NLGN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NLGN2-low versus NLGN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN2→partner) and Y-score (partner→NLGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.477	-2.201	.001	<.001	3	3
UCEC	MSH6 →	-0.354	-2.115	.001	.016	3	2
UCEC	Notch1 →	+0.111	+1.710	.018	.025	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.345	-1.906	.022	.015	3	2
UCEC	Annexin-1 →	+0.623	+3.019	<.001	<.001	3	2
UCEC	ARID1A →	-0.158	-3.321	.012	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by NLGN2 expression — UCEC

Explore this box plot interactively →