NLGN2

Across TCGA cell cohorts, NLGN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,836 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLGN2-associated GO terms across cancer lineages are Regulation of respiratory gaseous exchange by nervous system process, Postsynaptic density protein 95 clustering, and Regulation of translation at synapse, modulating synaptic transmission. Each is linked with NLGN2 in more than 17 cancer types. Because this analysis shows association rather than direction, both NLGN2-to-partner and partner-to-NLGN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of respiratory gaseous exchange by nervous system process grouped by NLGN2-low versus NLGN2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN2→partner) and Y-score (partner→NLGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of respiratory gaseous exchange by nervous system process →	+1.699	+1.847	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Postsynaptic density protein 95 clustering →	+1.573	+2.305	<.001	<.001	3	18
PANCREAS	Regulation of translation at synapse, modulating synaptic transmission →	+0.128	+1.322	<.001	<.001	3	16
LUNG_SCLC	Thigmotaxis →	+0.364	+1.486	<.001	<.001	3	16
STOMACH	Negative regulation of smoothened signaling pathway →	+0.077	+2.026	<.001	<.001	3	16
BREAST	Protein localization to endosome →	+0.161	+1.482	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,836 associations by consensus.

Regulation of respiratory gaseous exchange by nervous system process by NLGN2 expression — URINARY_TRACT

Explore this box plot interactively →