NLGN2

Across TCGA cell cohorts, NLGN2 mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLGN2-associated genes across cancer lineages are OR2M5, OR10S1, and SLC22A12. Each is linked with NLGN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN2-to-partner and partner-to-NLGN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by NLGN2-low versus NLGN2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN2→partner) and Y-score (partner→NLGN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR2M5 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR10S1 →	+0.031	+4.930	<.001	.008	3	1
URINARY_TRACT	SLC22A12 →	+0.006	+5.087	<.001	.004	3	1
CNS	GABRA4 →	+1.048	+2.490	<.001	.008	3	1
CNS	PRAMEF10 →	+0.130	+3.754	.001	<.001	3	1
CNS	DUXA →	+0.034	+2.874	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

OR2M5 by NLGN2 expression — SOFT_TISSUE

Explore this box plot interactively →