NLGN1

Across TCGA pan-cancer cohorts, NLGN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NLGN1 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NLGN1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NLGN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, UCEC, and COAD are the cancer types where NLGN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.067	0.865	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.937	0.429	.007	30	view →
COAD	DFS	Median	III,IV	0.307	0.655	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NLGN1–KIRC (DFS)

Open the KIRC breakdown →