NLGN1

Across TCGA patient cohorts, NLGN1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN1-associated genes across cancer lineages are Cyclin-B1, FASN, and PDCD4. Each is linked with NLGN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLGN1-to-partner and partner-to-NLGN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by NLGN1-low versus NLGN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN1→partner) and Y-score (partner→NLGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.740	+2.222	<.001	<.001	3	5
LUSC	FASN →	+0.813	+2.231	<.001	.006	3	4
LUSC	PDCD4 →	-0.483	-2.194	.002	.010	3	4
LUAD	FoxM1 →	+0.399	+2.203	<.001	.031	3	4
UCEC	PCNA →	+0.194	+2.222	.003	.009	3	4
UCEC	C-Raf →	+0.182	+2.459	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Cyclin-B1 by NLGN1 expression — UCEC

Explore this box plot interactively →