NLGN1

Across TCGA cell cohorts, NLGN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,645 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NLGN1-associated GO terms across cancer lineages are Regulation of circadian sleep/wake cycle, wakefulness, Positive regulation of circadian sleep/wake cycle, wakefulness, and Regulation of neuromuscular synaptic transmission. Each is linked with NLGN1 in more than 18 cancer types. Because this analysis shows association rather than direction, both NLGN1-to-partner and partner-to-NLGN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of circadian sleep/wake cycle, wakefulness grouped by NLGN1-low versus NLGN1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN1→partner) and Y-score (partner→NLGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of circadian sleep/wake cycle, wakefulness →	+1.949	+2.558	<.001	<.001	3	19
KIDNEY	Positive regulation of circadian sleep/wake cycle, wakefulness →	+1.753	+2.560	<.001	<.001	3	19
SOFT_TISSUE	Regulation of neuromuscular synaptic transmission →	+1.499	+1.596	<.001	<.001	3	16
SOFT_TISSUE	Positive regulation of neuromuscular synaptic transmission →	+1.499	+1.596	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Terminal button organization →	-0.245	-1.741	.005	.001	3	13
OVARY	Synaptic vesicle targeting →	-0.229	-1.017	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,645 associations by consensus.

Regulation of circadian sleep/wake cycle, wakefulness by NLGN1 expression — KIDNEY

Explore this box plot interactively →