NKX3-2

Across TCGA pan-cancer cohorts, NKX3-2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NKX3-2 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NKX3-2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NKX3-2 expression acts as an unfavorable survival marker.

COAD, SCLC, and UCEC are the cancer types where NKX3-2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.183	0.806	.004	17	view →
SCLC	OS	Median	All	0.082	0.822	<.001	6	view →
UCEC	DFS	Median	III,IV	0.049	0.572	.007	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NKX3-2–COAD (OS)

Open the COAD breakdown →