NKTR

Across TCGA pan-cancer cohorts, NKTR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NKTR data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NKTR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKTR expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where NKTR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.299	0.786	<.001	42	view →
LUAD	DFS	Tertile	III,IV	0.922	0.434	.001	38	view →
HNSC	DFS	Quartile	All	0.937	0.746	.009	10	view →
OV	DFS	Median	All	1.000	0.847	.022	4	view →
PDAC	OS	Quartile	II,III,IV	0.394	0.638	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NKTR–CCRCC (DFS)

Open the CCRCC breakdown →