NKTR

Across TCGA patient cohorts, NKTR mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKTR-associated genes across cancer lineages are Bax, Caspase-8, and EGFR_pY1068. Each is linked with NKTR in more than 2 cancer types. Because this analysis shows association rather than direction, both NKTR-to-partner and partner-to-NKTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by NKTR-low versus NKTR-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKTR→partner) and Y-score (partner→NKTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	Bax →	+0.179	+1.999	.008	.029	3	3
UCEC	Caspase-8 →	-0.243	-1.632	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.181	-1.106	.010	.020	3	2
UCEC	eIF4E →	+0.157	+2.515	.008	<.001	3	2
UCEC	GAPDH →	+0.320	+0.947	.034	.047	3	2
UCEC	mTOR_pS2448 →	-0.106	-1.834	.011	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Bax by NKTR expression — BLCA

Explore this box plot interactively →