NKTR

Across TCGA cell cohorts, NKTR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,691 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NKTR-associated GO terms across cancer lineages are Regulation of double-strand break repair, Negative regulation of gene expression, epigenetic, and Viral translational termination-reinitiation. Each is linked with NKTR in more than 18 cancer types. Because this analysis shows association rather than direction, both NKTR-to-partner and partner-to-NKTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by NKTR-low versus NKTR-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKTR→partner) and Y-score (partner→NKTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of double-strand break repair →	+0.081	+1.668	<.001	<.001	3	19
OESOPHAGUS	Negative regulation of gene expression, epigenetic →	+0.066	+1.183	.002	.003	3	19
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.085	+1.630	<.001	<.001	3	19
LUNG_SCLC	Positive regulation of double-strand break repair →	+0.084	+1.491	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.062	+1.020	<.001	<.001	3	18
BONE	Subtelomeric heterochromatin formation →	+0.150	+1.436	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,691 associations by consensus.

Regulation of double-strand break repair by NKTR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →