NKTR

Across TCGA cell cohorts, NKTR mutation is significantly associated with the RNA expression of many other genes, with 526 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKTR-associated genes across cancer lineages are PYDC1, GCAT, and CBY1. Each is linked with NKTR in more than 1 cancer types. Because this analysis shows association rather than direction, both NKTR-to-partner and partner-to-NKTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC1 grouped by NKTR-low versus NKTR-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKTR→partner) and Y-score (partner→NKTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PYDC1 →	+0.322	+4.307	<.001	.004	3	1
LARGE_INTESTINE	GCAT →	+1.486	+3.628	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.521	+3.137	.004	.007	3	1
LARGE_INTESTINE	SGSM3 →	+0.653	+2.502	.003	.005	3	1
LARGE_INTESTINE	PHF5A →	+0.534	+3.628	.001	<.001	3	1
LARGE_INTESTINE	TRMU →	+0.603	+2.502	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

PYDC1 by NKTR expression — BONE

Explore this box plot interactively →