Across TCGA patient cohorts, NKRF mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKRF-associated genes across cancer lineages are ACC1, JNK_pT183_Y185, and JNK2. Each is linked with NKRF in more than 1 cancer types. Because this analysis shows association rather than direction, both NKRF-to-partner and partner-to-NKRF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKRF→partner) and Y-score (partner→NKRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.220	+1.598	.048	.040	3	2
UCEC	JNK_pT183_Y185 →	-0.209	-2.392	<.001	<.001	3	2
UCEC	JNK2 →	+0.192	+1.687	.001	.013	3	2
UCEC	p21 →	+0.140	+2.335	.017	.002	3	2
UCEC	p53 →	-0.251	-1.700	.034	.040	3	2
UCEC	Annexin-1 →	+0.760	+2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Exploration

NKRF survival (RNA) · tumor vs normal (RNA) · all NKRF data types