NKPD1

Across TCGA patient cohorts, NKPD1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKPD1-associated genes across cancer lineages are Caspase-7-cleavedD198, cIAP, and Collagen-VI. Each is linked with NKPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKPD1-to-partner and partner-to-NKPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NKPD1-low versus NKPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKPD1→partner) and Y-score (partner→NKPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.577	+1.604	.011	.041	3	2
UCEC	cIAP →	+0.119	+2.611	.023	<.001	3	2
UCEC	Collagen-VI →	-0.231	-3.571	.003	.002	3	2
UCEC	14-3-3_beta →	-0.099	-3.295	.009	.009	3	1
UCEC	eEF2 →	+0.353	+3.169	.010	.018	3	1
UCEC	EGFR_pY1068 →	-0.244	-2.321	.011	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Caspase-7-cleavedD198 by NKPD1 expression — UCEC

Explore this box plot interactively →