NKIRAS2

Across TCGA pan-cancer cohorts, NKIRAS2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated NKIRAS2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NKIRAS2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NKIRAS2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where NKIRAS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	1.000	0.740	.005	37	view →
COAD	DFS	Quartile	II,III,IV	1.000	0.877	.034	24	view →
LSCC	DFS	Tertile	All	0.945	0.702	.003	8	view →
UCEC	DFS	Median	All	0.961	0.846	.020	6	view →
PDAC	DFS	Quartile	II,III,IV	0.222	0.527	.031	6	view →
LUAD	OS	Quartile	All	1.000	0.577	.017	4	view →
GBM	OS	Median	All	0.635	0.889	.007	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

NKIRAS2–CCRCC (DFS)

Open the CCRCC breakdown →