NKIRAS2

Across TCGA patient cohorts, NKIRAS2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKIRAS2-associated genes across cancer lineages are MEK1, VHL, and ASNS. Each is linked with NKIRAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKIRAS2-to-partner and partner-to-NKIRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NKIRAS2-low versus NKIRAS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKIRAS2→partner) and Y-score (partner→NKIRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.460	+3.321	.016	.010	3	1
UCEC	VHL →	-1.024	-3.000	.003	.036	3	1
UCEC	ASNS →	+0.609	+3.000	.001	.036	2	1
UCEC	p62 Lck ligand →	+0.514	+3.321	.002	.010	1	1
UCEC	Cyclin-B1 →	+0.790	+3.321	.007	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by NKIRAS2 expression — UCEC

Explore this box plot interactively →