NKIRAS2

Across TCGA cell cohorts, NKIRAS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,544 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NKIRAS2-associated GO terms across cancer lineages are Negative regulation of transcription elongation by RNA polymerase II, Regulation of protein localization to nucleus, and Epigenetic regulation of gene expression. Each is linked with NKIRAS2 in more than 13 cancer types. Because this analysis shows association rather than direction, both NKIRAS2-to-partner and partner-to-NKIRAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription elongation by RNA polymerase II grouped by NKIRAS2-low versus NKIRAS2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKIRAS2→partner) and Y-score (partner→NKIRAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of transcription elongation by RNA polymerase II →	+0.110	+0.822	.003	.005	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to nucleus →	+0.089	+0.969	<.001	<.001	3	14
LARGE_INTESTINE	Epigenetic regulation of gene expression →	+0.050	+0.997	<.001	<.001	3	13
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.060	+0.908	<.001	<.001	3	13
OESOPHAGUS	mRNA transport →	+0.116	+1.012	.001	<.001	3	13
LARGE_INTESTINE	Regulation of transcription initiation by RNA polymerase II →	+0.071	+0.857	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,544 associations by consensus.

Negative regulation of transcription elongation by RNA polymerase II by NKIRAS2 expression — LUNG_NSCLC_LUSC

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