Across TCGA patient cohorts, NKIRAS1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKIRAS1-associated genes across cancer lineages are p90 RSK_pT359_S363, PREX1, and Rad50. Each is linked with NKIRAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKIRAS1-to-partner and partner-to-NKIRAS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKIRAS1→partner) and Y-score (partner→NKIRAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK_pT359_S363 →	+0.206	+2.817	.042	.036	3	1
UCEC	PREX1 →	+0.326	+2.321	.017	.035	3	1
UCEC	Rad50 →	-0.269	-2.321	.027	.035	3	1
UCEC	SF2 →	-0.130	-3.159	.018	.019	3	1
UCEC	14-3-3_beta →	-0.146	-3.446	.003	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

NKIRAS1 survival (RNA) · tumor vs normal (RNA) · all NKIRAS1 data types