NKILA

Across TCGA pan-cancer cohorts, NKILA RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NKILA data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NKILA RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKILA expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

CESC, LUSC, and UCS are the cancer types where NKILA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.425	0.642	<.001	90	view →
LUSC	DFS	Tertile	II,III,IV	0.257	0.497	.001	81	view →
UCS	DFS	Quartile	II,III,IV	0.546	0.162	.002	66	view →
KIRC	DFS	Median	IV	0.351	0.672	.001	51	view →
ACC	OS	Median	III,IV	0.318	0.878	.001	49	view →
COAD	DFS	Median	All	0.587	0.798	<.001	44	view →
LGG	DFS	Median	All	0.675	0.805	<.001	44	view →
LUAD	DFS	Median	All	0.190	0.458	<.001	36	view →
THCA	DFS	Tertile	IV	0.336	0.804	.010	33	view →
HNSC	OS	Median	All	0.701	0.801	<.001	33	view →
PAAD	OS	Quartile	All	0.474	0.761	.007	31	view →
BLCA	OS	Quartile	All	0.575	0.719	.011	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NKILA–CESC (DFS)

Open the CESC breakdown →