NKD2

Across TCGA patient cohorts, NKD2 mutation is significantly associated with the RNA expression of many other genes, with 1,276 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKD2-associated genes across cancer lineages are ESS2, MCAT, and ASCC2. Each is linked with NKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKD2-to-partner and partner-to-NKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ESS2 grouped by NKD2-low versus NKD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKD2→partner) and Y-score (partner→NKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ESS2 →	+0.315	+3.258	.001	<.001	3	2
UCEC	MCAT →	+0.378	+2.593	.005	.006	3	2
UCEC	ASCC2 →	+0.310	+3.732	.001	<.001	3	2
UCEC	POLR3H →	+0.503	+3.711	<.001	<.001	3	2
UCEC	SNX8 →	+0.432	+2.595	.006	<.001	3	2
SKCM	PLCD4 →	+0.914	+3.404	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,276 associations by consensus.

ESS2 by NKD2 expression — UCEC

Explore this box plot interactively →