NKD2

Across TCGA patient cohorts, NKD2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKD2-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and ERK2. Each is linked with NKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKD2-to-partner and partner-to-NKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NKD2-low versus NKD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKD2→partner) and Y-score (partner→NKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.224	+3.459	.010	.005	3	1
UCEC	A-Raf_pS299 →	-0.115	-2.321	.019	.034	3	1
UCEC	ERK2 →	+0.192	+2.321	.015	.033	3	1
UCEC	Fibronectin →	-0.272	-2.312	.045	.034	3	1
UCEC	JNK2 →	+0.285	+2.469	<.001	.010	3	1
UCEC	Ku80 →	+0.307	+2.335	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

eIF4E by NKD2 expression — UCEC

Explore this box plot interactively →