NKD2

Across TCGA cell cohorts, NKD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,052 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NKD2-associated GO terms across cancer lineages are Nucleoside triphosphate biosynthetic process, Ribonucleoside triphosphate biosynthetic process, and Positive regulation of DNA metabolic process. Each is linked with NKD2 in more than 10 cancer types. Because this analysis shows association rather than direction, both NKD2-to-partner and partner-to-NKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside triphosphate biosynthetic process grouped by NKD2-low versus NKD2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKD2→partner) and Y-score (partner→NKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleoside triphosphate biosynthetic process →	+0.096	+1.596	.002	<.001	3	11
LUNG_SCLC	Ribonucleoside triphosphate biosynthetic process →	+0.102	+1.650	.001	<.001	3	11
LUNG_SCLC	Positive regulation of DNA metabolic process →	+0.052	+1.326	.001	.002	3	10
SOFT_TISSUE	Actin-mediated cell contraction →	-0.089	-1.789	.003	.009	3	10
SOFT_TISSUE	Tertiary alcohol biosynthetic process →	+1.078	+1.602	.001	.002	3	10
SOFT_TISSUE	Cortisol biosynthetic process →	+1.078	+1.602	.001	.002	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,052 associations by consensus.

Nucleoside triphosphate biosynthetic process by NKD2 expression — LUNG_SCLC

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