NKAPD1

Across TCGA patient cohorts, NKAPD1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKAPD1-associated genes across cancer lineages are eIF4E, FoxM1, and INPP4B. Each is linked with NKAPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKAPD1-to-partner and partner-to-NKAPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NKAPD1-low versus NKAPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKAPD1→partner) and Y-score (partner→NKAPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.234	+2.700	<.001	<.001	3	2
UCEC	FoxM1 →	+0.178	+1.716	.033	.003	3	2
UCEC	INPP4B →	-0.217	-1.678	.038	.019	3	2
UCEC	PCNA →	+0.275	+2.321	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.449	+1.604	.019	.021	3	2
UCEC	14-3-3_beta →	-0.087	-2.295	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eIF4E by NKAPD1 expression — UCEC

Explore this box plot interactively →