NKAIN1

Across TCGA pan-cancer cohorts, NKAIN1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NKAIN1 data layer compared with 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NKAIN1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKAIN1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and UCS show a favorable association.

UCEC, BRCA, and UCS are the cancer types where NKAIN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.788	0.886	<.001	86	view →
BRCA	DFS	Median	III,IV	0.932	0.824	<.001	70	view →
UCS	DFS	Median	II,III,IV	0.610	0.267	.003	56	view →
BLCA	DFS	Median	II,III,IV	0.276	0.402	.001	46	view →
LGG	OS	Median	All	0.876	0.735	<.001	38	view →
LIHC	OS	Tertile	All	0.578	0.763	<.001	34	view →
THCA	OS	Quartile	II,III,IV	0.662	1.000	.005	31	view →
STAD	OS	Median	II,III,IV	0.608	0.735	.004	28	view →
LUAD	DFS	Tertile	All	0.539	0.764	<.001	25	view →
MESO	OS	Median	II,III,IV	0.455	0.673	.005	20	view →
HNSC	OS	Tertile	IV	0.692	0.520	.006	17	view →
KIRP	DFS	Quartile	All	0.823	0.959	.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NKAIN1–UCEC (DFS)

Open the UCEC breakdown →