NIT1

Across TCGA patient cohorts, NIT1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIT1-associated genes across cancer lineages are A-Raf_pS299, MSH6, and p27_pT198. Each is linked with NIT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIT1-to-partner and partner-to-NIT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by NIT1-low versus NIT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIT1→partner) and Y-score (partner→NIT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.117	-3.169	.043	.019	3	1
UCEC	MSH6 →	-0.498	-3.159	.001	.019	3	1
UCEC	p27_pT198 →	+0.151	+3.000	.003	.036	3	1
UCEC	PCNA →	+0.307	+2.459	.003	.020	3	1
UCEC	Annexin-1 →	+0.820	+3.189	.001	.010	3	1
UCEC	Shc_pY317 →	-0.186	-3.584	.011	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by NIT1 expression — UCEC

Explore this box plot interactively →