NISCH

Across TCGA pan-cancer cohorts, NISCH mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NISCH data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NISCH mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NISCH expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where NISCH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.996	0.703	.003	38	view →
CCRCC	OS	Quartile	All	1.000	0.461	.005	16	view →
HNSC	DFS	Tertile	IV	0.823	0.550	.009	9	view →
GBM	OS	Quartile	All	0.201	0.621	.012	4	view →
LUAD	DFS	Quartile	III,IV	0.338	0.953	.006	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NISCH–PDAC (OS)

Open the PDAC breakdown →