NISCH

Across TCGA patient cohorts, NISCH protein abundance is significantly associated with the RNA expression of many other genes, with 14,836 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NISCH-associated genes across cancer lineages are ADH1B, SEPTIN4, and C7. Each is linked with NISCH in more than 6 cancer types. Because this analysis shows association rather than direction, both NISCH-to-partner and partner-to-NISCH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NISCH versus ADH1B in COAD, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NISCH→partner) and Y-score (partner→NISCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ADH1B →	+1.517	+0.368	<.001	.001	3	7
GBM	SEPTIN4 →	+0.794	+0.142	.003	<.001	3	6
PDAC	C7 →	+1.870	+0.272	<.001	<.001	3	6
BRCA	CENPL →	-0.650	-0.313	<.001	<.001	3	6
LUAD	MYBL2 →	-1.302	-0.161	<.001	<.001	3	5
UCEC	ZDHHC15 →	+0.729	+0.192	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,836 associations by consensus.

NISCH vs ADH1B — COAD

Explore this scatter interactively →