NISCH

Across TCGA patient cohorts, NISCH mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NISCH-associated genes across cancer lineages are ATM, mTOR_pS2448, and Fibronectin. Each is linked with NISCH in more than 3 cancer types. Because this analysis shows association rather than direction, both NISCH-to-partner and partner-to-NISCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NISCH-low versus NISCH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NISCH→partner) and Y-score (partner→NISCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.505	-2.986	<.001	<.001	3	4
UCEC	mTOR_pS2448 →	-0.111	-1.571	.014	.032	3	3
STAD	Fibronectin →	+0.309	+2.342	.044	.019	3	2
STAD	TIGAR →	+0.369	+3.459	.046	.005	3	2
STAD	4E-BP1 →	+0.362	+3.000	.007	.034	3	2
UCEC	MEK1 →	+0.418	+2.222	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by NISCH expression — UCEC

Explore this box plot interactively →