NISCH

Across TCGA cell cohorts, NISCH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,685 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NISCH-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Microtubule nucleation, and Microtubule polymerization or depolymerization. Each is linked with NISCH in more than 18 cancer types. Because this analysis shows association rather than direction, both NISCH-to-partner and partner-to-NISCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by NISCH-low versus NISCH-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NISCH→partner) and Y-score (partner→NISCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of double-strand break repair →	+0.092	+0.854	<.001	.002	3	19
BONE	Microtubule nucleation →	+0.126	+1.210	<.001	<.001	3	19
LARGE_INTESTINE	Microtubule polymerization or depolymerization →	+0.121	+1.035	<.001	<.001	3	18
URINARY_TRACT	Subtelomeric heterochromatin formation →	+0.118	+1.075	.001	.003	3	18
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.148	+1.609	<.001	<.001	3	18
STOMACH	Positive regulation of DNA recombination →	+0.092	+0.980	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,685 associations by consensus.

Positive regulation of double-strand break repair by NISCH expression — STOMACH

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