NISCH

Across TCGA cell cohorts, NISCH mutation is significantly associated with the RNA expression of many other genes, with 1,354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NISCH-associated genes across cancer lineages are LY6G6F, C20orf85, and RAD51AP1. Each is linked with NISCH in more than 2 cancer types. Because this analysis shows association rather than direction, both NISCH-to-partner and partner-to-NISCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by NISCH-low versus NISCH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NISCH→partner) and Y-score (partner→NISCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LY6G6F →	+0.644	+2.163	.008	.009	3	3
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	2
BLOOD_Leukemia	RAD51AP1 →	+0.961	+3.548	<.001	.001	3	2
BLOOD_Leukemia	KANSL3 →	+0.739	+3.115	<.001	.009	3	2
BLOOD_Leukemia	OTX1 →	+1.044	+3.228	<.001	.004	3	2
BLOOD_Leukemia	BRCA1 →	+0.630	+3.489	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,354 associations by consensus.

LY6G6F by NISCH expression — BLOOD_Leukemia

Explore this box plot interactively →