NIPSNAP3A

Across TCGA pan-cancer cohorts, NIPSNAP3A mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NIPSNAP3A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NIPSNAP3A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NIPSNAP3A is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and CCRCC are the cancer types where NIPSNAP3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIPSNAP3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−0.817	<.001	9	view →
COAD	Male	II,III,IV	−0.504	<.001	9	view →
CCRCC	All	II,III,IV	−0.356	<.001	9	view →
LSCC	Male	III,IV	−0.727	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NIPSNAP3A–LUAD

Open the LUAD breakdown →