NIPSNAP3A

Across TCGA patient cohorts, NIPSNAP3A mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPSNAP3A-associated genes across cancer lineages are MEK1, p21, and p90 RSK_pT359_S363. Each is linked with NIPSNAP3A in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPSNAP3A-to-partner and partner-to-NIPSNAP3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NIPSNAP3A-low versus NIPSNAP3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPSNAP3A→partner) and Y-score (partner→NIPSNAP3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.402	+3.169	.045	.020	3	1
UCEC	p21 →	+0.227	+3.169	.031	.020	3	1
UCEC	p90 RSK_pT359_S363 →	+0.383	+3.009	<.001	.019	3	1
UCEC	YB-1_pS102 →	+0.324	+3.169	.001	.020	3	1
UCEC	C-Raf_pS338 →	+0.117	+2.834	.009	.034	3	1
UCEC	IGFBP2 →	-0.992	-3.169	.005	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MEK1 by NIPSNAP3A expression — UCEC

Explore this box plot interactively →