NIPSNAP2

Across TCGA patient cohorts, NIPSNAP2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPSNAP2-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and SF2. Each is linked with NIPSNAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPSNAP2-to-partner and partner-to-NIPSNAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by NIPSNAP2-low versus NIPSNAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPSNAP2→partner) and Y-score (partner→NIPSNAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-2.973	.015	.035	3	1
UCEC	FoxM1 →	+0.391	+3.321	.003	.010	3	1
UCEC	SF2 →	-0.133	-3.308	.020	.010	3	1
UCEC	Shc_pY317 →	-0.305	-3.000	<.001	.036	3	1
UCEC	Tuberin_pT1462 →	+0.282	+3.179	.020	.010	3	1
UCEC	VHL →	-1.247	-3.169	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by NIPSNAP2 expression — UCEC

Explore this box plot interactively →