Across TCGA pan-cancer cohorts, NIPSNAP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NIPSNAP1 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NIPSNAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NIPSNAP1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where NIPSNAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.481	0.729	.011	10	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
LSCC	DFS	Median	II,III,IV	0.988	0.854	.009	6	view →
GBM	DFS	Tertile	All	0.873	0.585	.015	6	view →
PDAC	OS	Median	All	0.577	0.393	.008	4	view →
LUAD	DFS	Median	All	0.569	0.875	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: NIPSNAP1 tumor-vs-normal RNA expression · all NIPSNAP1 data types