NIPBL

Across TCGA patient cohorts, NIPBL protein abundance is significantly associated with the RNA expression of many other genes, with 16,246 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NIPBL-associated genes across cancer lineages are PPIH, CEP72, and DROSHA. Each is linked with NIPBL in more than 6 cancer types. Because this analysis shows association rather than direction, both NIPBL-to-partner and partner-to-NIPBL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NIPBL versus PPIH in HNSC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPBL→partner) and Y-score (partner→NIPBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPIH →	+0.420	+0.198	<.001	<.001	3	7
UCEC	CEP72 →	+0.834	+0.281	<.001	<.001	3	6
HNSC	DROSHA →	+0.633	+0.258	<.001	<.001	3	6
HNSC	NUP155 →	+0.813	+0.324	<.001	<.001	3	6
HNSC	TFDP2 →	+1.011	+0.355	<.001	<.001	3	6
HNSC	MTBP →	+0.724	+0.291	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,246 associations by consensus.

NIPBL vs PPIH — HNSC

Explore this scatter interactively →