NIPBL

Across TCGA patient cohorts, NIPBL mutation is significantly associated with the RNA expression of many other genes, with 8,275 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPBL-associated genes across cancer lineages are PTMAP4, THOC5, and ZC3H14. Each is linked with NIPBL in more than 5 cancer types. Because this analysis shows association rather than direction, both NIPBL-to-partner and partner-to-NIPBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTMAP4 grouped by NIPBL-low versus NIPBL-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPBL→partner) and Y-score (partner→NIPBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PTMAP4 →	+1.181	+1.942	<.001	.002	3	6
STAD	THOC5 →	+0.348	+1.959	.002	.002	3	5
STAD	ZC3H14 →	+0.398	+4.038	<.001	<.001	3	5
STAD	KRR1 →	+0.372	+3.717	.001	<.001	3	5
STAD	LARS2 →	+0.572	+3.716	<.001	<.001	3	5
STAD	PHF13 →	+0.420	+3.597	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,275 associations by consensus.

PTMAP4 by NIPBL expression — STAD

Explore this box plot interactively →