NIPBL

Across TCGA patient cohorts, NIPBL mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPBL-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and 4E-BP1_pT70. Each is linked with NIPBL in more than 3 cancer types. Because this analysis shows association rather than direction, both NIPBL-to-partner and partner-to-NIPBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by NIPBL-low versus NIPBL-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPBL→partner) and Y-score (partner→NIPBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	mTOR_pS2448 →	-0.204	-3.700	<.001	.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.342	+2.146	<.001	<.001	3	4
LUSC	4E-BP1_pT70 →	+0.194	+2.331	.043	.019	3	3
STAD	eIF4E →	+0.193	+3.480	.002	.002	3	3
UCEC	MEK1 →	+0.293	+1.280	.002	.003	3	3
STAD	PCNA →	+0.357	+2.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

mTOR_pS2448 by NIPBL expression — STAD

Explore this box plot interactively →