NIPBL

Across TCGA cell cohorts, NIPBL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,539 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NIPBL-associated GO terms across cancer lineages are Replication-born double-strand break repair via sister chromatid exchange, Establishment of mitotic sister chromatid cohesion, and Establishment of sister chromatid cohesion. Each is linked with NIPBL in more than 19 cancer types. Because this analysis shows association rather than direction, both NIPBL-to-partner and partner-to-NIPBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication-born double-strand break repair via sister chromatid exchange grouped by NIPBL-low versus NIPBL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPBL→partner) and Y-score (partner→NIPBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Replication-born double-strand break repair via sister chromatid exchange →	+0.265	+1.240	<.001	<.001	3	20
OESOPHAGUS	Establishment of mitotic sister chromatid cohesion →	+0.167	+1.017	.002	.002	3	19
OVARY	Establishment of sister chromatid cohesion →	+0.162	+0.997	<.001	<.001	3	17
BONE	Protein localization to nuclear inner membrane →	+0.179	+0.564	<.001	<.001	3	16
LUNG_SCLC	Protein modification by small protein removal →	+0.053	+0.863	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.126	+0.822	.001	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,539 associations by consensus.

Replication-born double-strand break repair via sister chromatid exchange by NIPBL expression — URINARY_TRACT

Explore this box plot interactively →