NIPBL

Across TCGA cell cohorts, NIPBL mutation is significantly associated with the RNA expression of many other genes, with 2,111 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NIPBL-associated genes across cancer lineages are SERINC4, GCAT, and TEX44. Each is linked with NIPBL in more than 2 cancer types. Because this analysis shows association rather than direction, both NIPBL-to-partner and partner-to-NIPBL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERINC4 grouped by NIPBL-low versus NIPBL-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPBL→partner) and Y-score (partner→NIPBL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SERINC4 →	+0.292	+1.944	.002	.008	3	3
LARGE_INTESTINE	GCAT →	+1.414	+2.130	<.001	<.001	3	3
URINARY_TRACT	TEX44 →	+0.025	+5.044	<.001	<.001	3	2
SKIN	PTPN11 →	+0.512	+2.451	.003	.009	3	2
BLOOD_Lymphoma	DNAAF6 →	+0.032	+3.502	.006	.006	3	2
LARGE_INTESTINE	EIF3L →	+0.417	+1.961	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,111 associations by consensus.

SERINC4 by NIPBL expression — STOMACH

Explore this box plot interactively →