NIPAL4

Across TCGA pan-cancer cohorts, NIPAL4 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated NIPAL4 data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NIPAL4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NIPAL4 expression acts as an unfavorable survival marker.

HNSC are the cancer types where NIPAL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.522	0.959	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

NIPAL4–HNSC (DFS)

Open the HNSC breakdown →