NIPAL4

Across TCGA patient cohorts, NIPAL4 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NIPAL4-associated genes across cancer lineages are Smac, PKC-delta_pS664, and PKC-b-II_pS660. Each is linked with NIPAL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPAL4-to-partner and partner-to-NIPAL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smac grouped by NIPAL4-low versus NIPAL4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPAL4→partner) and Y-score (partner→NIPAL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Smac →	+0.340	+3.012	.011	.018	3	2
SKCM	PKC-delta_pS664 →	+0.245	+2.321	.008	.035	3	1
SKCM	PKC-b-II_pS660 →	+0.303	+2.321	.038	.035	3	1
SKCM	STAT3_pY705 →	-0.293	-3.169	.029	.018	2	2
SKCM	c-Kit →	-0.689	-2.321	.034	.035	3	1
UCEC	MEK1 →	+0.428	+3.169	.033	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Smac by NIPAL4 expression — SKCM

Explore this box plot interactively →